| The Effect of Caffeine and Probiotics on Constant Light-Induced Depression in Male Rats Model |
| Paper ID : 1069-ISCH |
| Authors |
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Asmaa M. Shamandy *1, Heba A. Elmasry2, Mona Abd- Rahman2, Rehab E. EL-Hennamy2 1Faculty of Science, Helwan university 2Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt |
| Abstract |
| Light pollution has become a potential health risk factor worldwide. Constant light and dim light at night increase depression-like behavior and have mixed effects on anxiety-like behavior in rodents. Probiotics and caffeine affect brain functions so they can alleviate depressive-like behaviors. The study aimed to examine the effect of caffeine and probiotics on depressive-like symptoms induced by constant light in male rats' models. Sixty-three rats were divided into six groups: control group; constant light group that was maintained under 24 h light (LL); constant light and caffeine group that was maintained under LL and administered orally with caffeine; constant light and probiotic group that was maintained under LL and administered orally with probiotic; constant light and antidepressant group that was maintained under LL and administered orally with antidepressant; constant light and caffeine + probiotic group. After two weeks, rats were sacrificed and brains were removed to assess dopamine, norepinephrine, serotonin, glutathione, and malondialdehyde daily profiles in the cerebral cortex. After caffeine and probiotic administration, dopamine and norepinephrine levels exhibited non-significant change compared to the constant light group. However, serotonin levels were increased in the caffeine group as compared to the constant light group. The level of malondialdehyde was decreased and glutathione levels were increased, at most time points of the study, after the administration of caffeine and probiotics. Conclusion: caffeine and probiotics can alleviate depressive-like behaviors induced by constant light, restore neurotransmitter levels, and decrease oxidative stress in the cerebral cortex of rats. |
| Keywords |
| Depression, constant light, caffeine, probiotics, neurotransmitters, oxidative stress |
| Status: Abstract Accepted (Poster Presentation) |