| Bioactive Secondary Metabolites from Aquatic Actinomycetes |
| Paper ID : 1006-ISCH |
| Authors |
|
Amr S, Refaay *1, Mohamed Saleh Abdelfattah2, Menna Allah Amin Hussein3, Gamal Ahmed Singer3 1Chemistry Department, Faculty of Science, Helwan university. 2Marine Natural Products Research Unit, Faculty of Science, Helwan University 3Chemistry Department, Faculty of Science, Helwan University. |
| Abstract |
| Actinomycetes are Gram-positive bacteria known for their complex morphological differentiation. They are renowned for producing a wide variety of bioactive compounds and are a focal point in the search for new therapeutic agents. In this study, we used chemical screening to investigate the crude extracts from several actinomycete strains isolated from various lakes in Egypt to assess their metabolic potential. A number of the isolated strains biosynthesize a promising bioactive metabolite, with the actinomycete 5M2 being particularly notable. Methanol extract of actinomycete 5M2 exhibited a relatively non-polar yellow bands on thin-layer chromatography (TLC). The distinct chromatographic profile characterized by orange UV fluorescence (365 nm), a reddish-brown color upon charring with H₂SO₄, and an orange reaction with 2N NaOH is indicative of a unique metabolite, likely belonging to a specific class of natural products. Herein, we report the fermentation, isolation, structural elucidation, and biological evaluation of the metabolites produced by this strain. |
| Keywords |
| Actinomycetes, Bioactive compounds, Natural product. |
| Status: Abstract Accepted (Poster Presentation) |