| Overview of the Effects of Nanometal Particles Against Schistosomiasis |
| Paper ID : 1009-ISCH |
| Authors |
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Mona F Khalil *1, Amira Anwar Bauomy1, Marwa SM Diab2, Mohamed Abdel-Moneim Dkhil1 1Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt 2Molecular Drug Evaluation Department, National Organization for Drug Control & Research, Giza, Egypt |
| Abstract |
| Nanomedicine has emerged as a vital approach in treating human diseases, including parasitic infections like schistosomiasis, a major health concern in tropical regions. Despite Praziquantel being the primary antischistosomal drug, its limitations, such as ineffectiveness against immature worms and the rise of drug-resistant Schistosoma strains, necessitate the development of new treatments. Recent studies have investigated the therapeutic potential of gold and selenium nanoparticles in minimizing tissue damage in mice infected with Schistosoma mansoni. The nanoparticles were carefully characterized using transmission electron microscopy to ensure their structural integrity and administered separately to assess their individual efficacy. S. mansoni infection led to significant oxidative stress and histological damage in various organs, including the liver, intestines, and spleen. However, treatment with these metal nanoparticles significantly reduced oxidative stress and histological impairment, highlighting their protective role and potential as therapeutic agents against S. mansoni infection. These findings suggest that gold and selenium nanoparticles may offer a promising alternative or complementary approach to traditional treatments for schistosomiasis. |
| Keywords |
| Schistosomiasis, gold nanoparticles, selenium nanoparticles, Oxidative stress, Histopathology |
| Status: Abstract Accepted (Oral Presentation) |