| Chemical Constituents and Isolation of Bioactive Compounds from the Medicinal Herb Ruta graveolens L. |
| Paper ID : 1014-ISCH |
| Authors |
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Sally A Lotfy *, Ahmed E Abdel Moneim, Mohamed S Abdelfattah Faculty of Science, Helwan University, Cairo, Egypt. |
| Abstract |
| Ruta graveolens L. (Rutaceae), widely used in traditional medicine, is valued for its therapeutic potential in treating neurological, pulmonary, digestive, gynaecological, and parasitic disorders. This study investigated the chemical composition, phytoconstituents, and isolation of natural compounds from R. graveolens. Proximate analysis revealed the contents of protein (11.0%), crude fibre (32.6%), carbohydrates (41.34%), and fats (2.88%), with iron (345 mg/100 g) being the predominant mineral. Amino acid profiling showed aspartic acid, glutamic acid, and proline as the major free amino acids, while HPLC analysis confirmed the presence of mannan, β-glucan, and sucrose. Total phenolic and flavonoid contents were 427.56 mg/g and 268.4 mg/100 g, respectively, with a strong antioxidant capacity (749.6 mg/100 g). Fractionation and purification of the methanolic extract yielded three compounds: kokusaginin, 1-hydroxy-3,4-dimethoxy-10-methylacridone, and rutin, whose structures were confirmed by mass spectrometry and NMR. These findings highlight R. graveolens as a rich source of bioactive metabolites with potential applications in drug discovery and natural therapeutics. |
| Keywords |
| Natural Products, Medicinal Herb, Ruta graveolens L., NMR |
| Status: Abstract Accepted (Poster Presentation) |