| The Potential Role of Spirulina on Chlorpyrifos-Induced Hepatotoxicity In Adult Male Albino Rats |
| Paper ID : 1021-ISCH |
| Authors |
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Menna Mohammed Hassan *1, Nabil Ahmed El-Yammany2, Ahmed Essmat Abdelmoneim2, Fatma El-Zahraa Hussain2, Heba Abd-elhamid El-masry2 1Assistant professor in faculty of science Helwan university 2Professor in science faculty, Helwan University |
| Abstract |
| Background and Aim: The current study designed to estimate spirulina’s (SP) potential role against chlorpyrifos-triggered hepatotoxicity in adult male albino rats. Experimental Approach: 28 male albino rats were categorized to 4 groups (n=7) as following: a control group; a chlorpyrifos group that received chlorpyrifos (5 mg/kg; daily oral administration); a spirulina group that received SP (500 mg/kg; daily oral administration); and a fourth group that received SP 1 h after CPF administration for 21 days. Key Findings and Conclusions: CPF intoxication increased ALT, AST, and ALP levels. Also, there was elevation in the content of oxidative stress biomarkers (NO and MDA) contaminants with significant reduction in SOD, CAT, and GSH concentration as antioxidant indicators. Furthermore, animals’ liver intoxicated with CPF recorded a significant elevation IL-1β, IL-6, TNF-α, and NF-κB as indicators for inflammation as well as apoptosis biomarkers (Caspase-3 and Bax). At the same time, there was a marked decrease in anti-apoptotic markers (Bcl-2). However, the post-treatment of SP restrained the induction of oxidative damage, cell inflammation, and cell apoptosis with marked live tissue preservation e. In conclusion: The present study showed that SP has free radical scavenging, inflammation-suppressing, and apoptosis-inhibiting properties in hepatic tissue of CPF-intoxicated male albino rats. |
| Keywords |
| Chlorpyrifos; Spirulina; hepatotoxicity; Inflammation; Apoptosis |
| Status: Abstract Accepted (Poster Presentation) |