| Synthesis, Biological Activity, Molecular Docking and Molecular Modelling of New 11-Hydrazineylidene-11H-indeno[1,2-b]quinoxaline Derivatives |
| Paper ID : 1027-ISCH |
| Authors |
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Ghada Ahmed Ezzat EL-deken *1, Fatma Abd ElGhany El-Samahy2, Ehab Mohamed Zayed2, Fayez Hassan Osman2, Khaled Mahmoud Mohamed3, Galal Hamza Elgemeie4 1Department of Green Chemistry, Chemical Industries Research Institute, National Research Centre, 33 El‑ Buhouth St, Dokki, Giza, Egypt, PO 12622 2Department of Green Chemistry, Chemical Industries Research Institute, National Research Centre, 33 El‑ Buhouth St, Dokki, Giza, Egypt, PO 12622. 3Pharmacognosy Department, National Research Centre, 33 El‑Buhouth St, Dokki, Giza, Egypt, PO 12622. 4Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt. |
| Abstract |
| Indenoquinoxaline has been found to exhibit various biological properties and therapeutic value such as antitumor activity. acetylcholinesterase (AChE) inhibitoryα-glucosidase inhibition and c-Jun N-terminal kinase (JNK) inhibition Hydrazone compounds represent an important area of research that includes, among others, synthetic approaches and biological studies. As a part of our aim to develop promising anticancer agents, a series of new 11-hydrazineylidene-11H-indeno[1,2-b]quinoxaline derivatives were synthesized. An unexcepted series of phosphonates were formed by the reaction of hydrazone derivative with dialkyl phosphites. Also , Novel compounds were proposed from the reaction of hydrazone with carbonyl compounds Characterizations of the new compounds have been determined using spectral data (IR, MS, NMR), fundamental analyses and single crystal X-ray diffraction technique. The ten of the new synthesized compounds were tested for anticancer activity in vitro in two human cancer cell lines: the HCT‐116 colon cancer cell line and the MCF‐7 breast cancer cell line. Some of the tested compounds demonstrated strong antitumor activities |
| Keywords |
| 11-Hydrazineylidene-11H-indeno[1,2-b]quinoxaline derivatives, Phosphonates, Carbonyl Compounds , Antitumor activities. |
| Status: Abstract Accepted (Poster Presentation) |