| The Effect of selenium nanoparticles biosynthesized by green coffee on diabetic rats |
| Paper ID : 1033-ISCH |
| Authors |
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Nader zakaria Essa * faculty of science Helwan university |
| Abstract |
| IIt is well acknowledged that the main symptoms of diabetes are hyperglycemia, hyperlipidemia, insulin resistance (IR), and inflammation. Together, these can enhance the production of reactive oxygen species (ROS), which make diabetes problems. IR is caused by obesity. Excess adiposity and adipocyte dysfunction result in impaired regulation of a wide range of adipokines. Adipokine regulation is hampered by excessive adiposity and dysfunctional adipocytes. Through changes in lipid and glucose balance as well as inflammatory reactions, these may help to develop a number of metabolic illnesses. Leptin, a significant adipokine, is essential for controlling body weight and fat mass. For the treatment of obesity and a reduction in diabetes consequences that damage hepatocytes, downregulation of fat formation is a suitable approach. Unfortunately, diabetes alters the expression of genes involved in glycolysis and gluconeogenesis, including pyruvate kinase, G6PD, IRS-1, hexokinase, and glucokinase; therefore, any method to enhance these changed proteins and/or genes can aid in postponing diabetes-related hepatocyte damage. Through the suppression of insulin signalling, the oxidative stress markers NO and MDA as well as the inflammatory cytokines TNF- and IL-1 are crucial for the pathophysiology and development of liver disease. The green that used in treatment of diabetes, is one of these naturally occurring goods. Diterpenes, trigonelline, and chlorogenic acid (CGA), among other bioactive substances with antioxidant capabilities, are abundant in green coffee bean water extract (GCBE). CGA, the primary phenolic component in GCBE, has been linked to numerous advantageous benefits. |
| Keywords |
| green coffee diabetes melletus oxidative stress |
| Status: Abstract Accepted (Poster Presentation) |