| Targeting Neuro-Cytokine Crosstalk and Molecular Apoptotic Pathways: Protective Phytoestrogenic Actions of Glycyrrhiza glabra and Trifolium pratense |
| Paper ID : 1053-ISCH |
| Authors |
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Fatma Elzahraa Hussien Salem * Professor of Physiology - Zoology and Entomology Department - Faculty of Science - Helwan University |
| Abstract |
| Menopause-associated estrogen deficiency induces a cascade of neuroendocrine, metabolic, and molecular disturbances, including weight gain, lipid dysregulation, oxidative stress, neuroinflammation, and apoptosis. The current study evaluated the potential protective effects of Glycyrrhiza glabra (Licorice) and Trifolium pratense (Red Clover) extracts in an ovariectomized (OVX) rat model mimicking postmenopausal conditions. Forty adult female Wistar rats were divided into four groups: sham-operated control, OVX, OVX + Licorice, and OVX + Red Clover. Treatments were administered orally at 500 mg/kg/day for 30 consecutive days. Biochemical assessments included hypothalamic serotonin (5-HT), serum gonadotropins (GnRH, FSH, LH), lipid profile, uterine and brain estrogen receptors (ER-α, ER-β), oxidative stress markers (MDA, NO, GSH), inflammatory cytokine TNF-α, and apoptotic proteins (Bax, caspase-3, BCL2). Therefore, ovariectomy significantly disrupted all measured parameters. Their efficacy in restoring hormonal feedback, reducing oxidative burden, and preserving neuronal and metabolic integrity underscores their potential as natural, safer alternatives to conventional hormone replacement therapy. |
| Keywords |
| Phytoestrogens; Ovariectomy; Neuroinflammation; Cytokines; Oxidative stress; Apoptosis |
| Status: Abstract Accepted (Oral Presentation) |