| Cracking Hypoxia: Making Liver Cancer Treatments Work Better, When Tumors Can’t Breathe. |
| Paper ID : 1064-ISCH |
| Authors |
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ismail Mohamed Emad Tantawy *1, magdy mohamed khalil2, medhat wahba shafaa3 1Faculty of Science Helwan University 2Faculty of Science, Helwan University 2School of Applied Health Sciences, Badr University in Cairo (BUC) 3faculty of science - helwan university |
| Abstract |
| Tumor hypoxia is a hallmark of solid cancers and one of the major reasons behind therapeutic resistance. When cancer cells adapt to oxygen deficiency, they become more aggressive, more angiogenic, and less responsive to conventional chemotherapy and radiotherapy. This adaptive resistance has long been considered a barrier, but it may also represent a possibility: hypoxia can be transformed from an enemy into a therapeutic target. Novel strategies are currently being developed to overcome oxygen-related resistance in hepatocellular carcinoma (HCC) Instead of relying on a single line of treatment, combinatorial approaches appear promising. Each strategy aims to re-sensitize hypoxic tumor cells and to transform oxygen deficiency into an opportunity for therapy rather than a limitation, creating room for broader and more effective applications. The evaluation of these multi-modal approaches highlights a new way of thinking about cancer treatment and opens the door for more effective regimens that target the biological complexity of cancer and provide new directions for clinical translation. |
| Keywords |
| Hypoxia, Hepatocellular Carcinoma, Combination therapy, Therapeutic resistance. |
| Status: Abstract Accepted (Poster Presentation) |