| Synthesis of dimethylcarbamothioyl)sulfanyl]-β-D-galactopyranose as a renewable scaffold with promising potential in green chemistry |
| Paper ID : 1091-ISCH |
| Authors |
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Reham A Mohamed-Ezzat *1, Galal H Elgemeie2 11Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo, Egypt. 22Chemistry Department, Faculty of science, Helwan University, Cairo, Egypt |
| Abstract |
| Thioglycosides have drawn a lot of attention as they act as glycosyl donors in a number of chemical reactions. They can be activated for glycosylation under a variety of conditions and are compatible with the most typical manipulations of carbohydrate-protecting groups. Their stability in such procedures is an additional advantage. Owing to the great diversity of their molecular structures, oligosaccharides and glycoconjugates exhibit a broad spectrum of biological functions. Because of their biological significance, they are particularly interesting synthetic targets. Synthetic carbohydrate chemistry has long been a key topic of interest in organic chemistry. Furthermore, it has been found that certain thioglycoside derivatives block the glycosylation of proteins. Herein, we report the synthesis of the N,N-dimethylcarbamodithio(2,3,4,6-tetra-O-acetyl-β-D-galactopyranose) by reacting the cyanocarbonimidodithioate derivative with the protected α-D-galactopyranosyl bromide at room temperature. As a renewable, biodegradable sugar-derived intermediate that facilitates more effective, catalytic, and enzyme-compatible glycosylation techniques and offers a bio-based substitute for petrochemical scaffolds, this compound can play a role in green chemistry and represents a promising intermediate for developing glycosylation strategies. |
| Keywords |
| Synthesis, thiocarbamate, crystal structure. |
| Status: Abstract Accepted (Poster Presentation) |