| Propolis Attenuates Thioacetamide-Induced Pulmonary Injury via Antioxidant and Anti-Inflammatory Mechanisms |
| Paper ID : 1100-ISCH |
| Authors |
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Asmaa Ahmed Mohamed * Faculty of science helwan university |
| Abstract |
| Introduction: Thioacetamide is one of the organo-sulfur compounds, their possible hazards are not fully studied. Overproduction of oxidant species is the main mechanism of Thioacetamide-induced histological changes in many organs. Propolis is a wax-like bee product with powerful anti-inflammatory and antioxidant properties. Objectives: This study aimed to evaluate the protective effect of Propolis in attenuating Thioacetamide-induced lung injury via antioxidant and anti-inflammatory mechanisms. Materials and Methods: Forty adult male albino rats were divided into four groups: (I) Control group received distilled water; (II) Propolis group (500mg/kg); (III) Thioacetamide group (100mg/kg); (IV) Propolis + Thioacetamide group. After 28 days, rats were sacrificed and lung samples were collected for histological, immunohistochemical and Biochemical studies. Data was statistically analyzed. Results: Groups I and II showed normal lung structure. Thioacetamide group revealed distorted lung tissues, collapsed alveoli, compensatory dilatation, hemosiderin granules, thickened inter-alveolar septa, inflammatory infiltrates, congested blood vessels, and collagen deposition with mast cell accumulation. Significant decreases in SOD, CAT, GSH, and Bcl-2 were observed, with increases in MDA, NO, and Bax. Co-administration of Propolis restored lung tissue integrity. Conclusion: Thioacetamide induces severe lung tissue damage. Propolis exerted a protective role when co-administered, suggesting its supplementation for individuals exposed to Thioacetamide. |
| Keywords |
| Thioacetamide, Propolis, Antioxidant, Lung injury, Histopathology |
| Status: Abstract Accepted (Poster Presentation) |